Thursday, April 25, 2013

Small Business Finance SaaS Provider Wave Launches Payroll App ...

Toronto-based Wave, the online finance software startup that has built a growing business around a freemium model of cloud-based accounting, is launching its new iOS payroll application today. The tool is a companion to the company?s web-based payroll platform, adding a much-needed mobile element to the overall product suite and building on the recent launch of the receipt scanner applications the company debuted earlier this month.

The iOS payroll app is designed to help SMB owners to run their entire payroll process from their iPhones, without having to jump on?the?desktop to do things like view a payroll history, run a new cycle, pay stubs and receive notifications to remind them of tasks that need completion. Notifications can be set for employees, too, to alert you exactly them a payment has been received. The app is debuting on Android, but CEO Kirk Simpson told me that the company is working on an Android version, too, with the intention of releasing that later this year.

The mobile app has been one of the top requests from Wave?s 600,000 current subscribers, and adds to Wave?s?continuing?efforts to build out that part of its business. Its freemium model appears to be working well so far, with the basic accounting tools available to all via an ad-supported revenue model, and additional tools, including the payroll suite, available on volume-based pricing. Moving mobile, which is a huge area of potential growth for SaaS-based offerings, si a good way for Wave to keep up with new players and stay ahead of legacy offerings.


November 16, 2010

C$18.5M

Wave is an integrated online solution designed for small businesses. There are several tools that work together, so small business owners have the insights and tools they need, all with one login. 1) Accounting by Wave is totally free. It?s a full double-entry accounting app, with financial dashboards, reporting, bank connections to avoid manual entry, and more. Guest collaborator features allow you to collaborate with a trusted accountant, bookkeeper or business partner, all in real time. Track multiple businesses...

? Learn more

Source: http://techcrunch.com/2013/04/24/small-business-finance-saas-provider-wave-launches-payroll-app-for-ios/

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Wednesday, April 24, 2013

Logitech's FabricSkin keyboard folio for iPad will shrug off spills for $149 (video)

Logitech's FabricSkin keyboard folio for iPad will shrug off spills for $149 (video)

When Logitech announced keyboard folios for the iPad and iPad Mini less than a month ago, it thought it had all bases covered: keyboard, stand, cover. One important group of people weren't considered in the design brief, however: so-called spillers, those with an uncanny ability to bring gadgets and beverages together. It's no wonder, then, that Logitech has been quick to come up with the FabricSkin keyboard folio to cater for this demographic. In addition to the "liquid-repellent FabricSkin surface" that coats the folio, there are a couple of new color schemes to choose from, and the Bluetooth keyboard is now without openings, similar to the Surface Touch Cover, so fluid can't work its way in between the keys. You'll be paying a premium for that peace of mind, though, as the FabricSkin folio for the iPad 2 and up (no iPad Mini version), set to launch in May, is now available to pre-order from Logitech for $149 (or £129) -- $50 more than the standard cover. Still, if there's a good chance you'd hydrate a normal folio eventually, the FabricSkin model is almost like getting a replacement at half price. We'll drink to that.

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Source: http://www.engadget.com/2013/04/23/logitech-fabricskin-keyboard-folio-for-ipad/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Is it the weather or the sequester? (Washington Bureau)

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Scientists map all possible drug-like chemical compounds

Tuesday, April 23, 2013

Drug developers may have a new tool to search for more effective medications and new materials.

It's a computer algorithm that can model and catalogue the entire set of lightweight, carbon-containing molecules that chemists could feasibly create in a lab.

The small-molecule universe has more than 10^60 (that's 1 with 60 zeroes after it) chemical structures. Duke chemist David Beratan said that many of the world's problems have molecular solutions in this chemical space, whether it's a cure for disease or a new material to capture sunlight.

But, he said, "The small-molecule universe is astronomical in size. When we search it for new molecular solutions, we are lost. We don't know which way to look."

To give synthetic chemists better directions in their molecular search, Beratan and his colleagues -- Duke chemist Weitao Yang, postdoctoral associates Aaron Virshup and Julia Contreras-Garcia, and University of Pittsburgh chemist Peter Wipf -- designed a new computer algorithm to map the small-molecule universe.

The map, developed with a National Institutes of Health P50 Center grant, tells scientists where the unexplored regions of the chemical space are and how to build structures to get there. A paper describing the algorithm and map appeared online in April in the Journal of the American Chemical Society.

The map helps chemists because they do not yet have the tools, time or money to synthesize all 10^60 compounds in the small-molecule universe. Synthetic chemists can only make a few hundred or a few thousand molecules at a time, so they have to carefully choose which compounds to build, Beratan said.

The scientists already have a digital library describing about a billion molecules found in the small-molecule universe, and they have synthesized about 100 million compounds over the course of human history, Beratan said. But these molecules are similar in structure and come from the same regions of the small-molecule universe.

It's the unexplored regions that could hold molecular solutions to some of the world's most vexing challenges, Beratan said.

To add diversity and explore new regions to the chemical space, Aaron Virshup developed a computer algorithm that built a virtual library of 9 million molecules with compounds representing every region of the small-molecule universe.

"The idea was to start with a simple molecule and make random changes, so you add a carbon, change a double bond to a single bond, add a nitrogen. By doing that over and over again, you can get to any molecule you can think of," Virshup said.

He programed the new algorithm to make small, random chemical changes to the structure of benzene and then to catalogue the new molecules it created based on where they fit into the map of the small-molecule universe. The challenge, Virshup said, came in identifying which new chemical compounds chemists could actually create in a lab.

Virshup sent his early drafts of the algorithm's newly constructed molecules to synthetic chemists who scribbled on them in red ink to show whether they were synthetically unstable or unrealistic. He then turned the criticisms into rules the algorithm had to follow so it would not make those types of compounds again.

"The rules kept us from getting lost in the chemical space," he said.

After ten iterations, the algorithm finally produced 9 million synthesizable molecules representing every region of the small-molecule universe, and it produced a map showing the regions of the chemical space where scientists have not yet synthesized any compounds.

"With the map, we can tell chemists, if you can synthesize a new molecule in this region of space, you have made a new type of compound," Virshup said. "It's an intellectual property issue. If you're in the blank spaces on our small molecule map, you're guaranteed to make something that isn't patented yet," he said.

The team has made the source code for the algorithm available online. The researchers said they hope scientists will use it to immediately start mining the unexplored regions of the small molecule universe for new chemical compounds.

###

Duke University: http://www.duke.edu

Thanks to Duke University for this article.

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Source: http://www.labspaces.net/127863/Scientists_map_all_possible_drug_like_chemical_compounds

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Strengthening legumes to tackle fertilizer pollution

Apr. 23, 2013 ? The overuse of nitrogen fertilizers in agriculture can wreak havoc on waterways, health and the environment.

An international team of scientists aims to lessen the reliance on these fertilizers by helping beans and similar plants boost their nitrogen production, even in areas with traditionally poor soil quality.

Researchers from the Center of Plant Genomics and Biotechnology at the Technical University of Madrid (UPM) and the Advanced Photon Source (APS) at the U.S. Department of Energy's Argonne National Laboratory report as an advance article April 5 for the Metallomics journal of The Royal Society of Chemistry on how to use X-ray analysis to map a path to increasing the amount of nitrogen that legumes deposit into the soil.

Cultivation of legumes, the plant family that includes peas, beans, alfalfa, soybeans, and peanuts, is one of the main ways farmers add natural nitrogen to agricultural fields. Rotating bean and corn crops to take advantage of the nitrogen beans deposit in the soil has long been a global farming tradition. Legumes use iron in the soil to carry out a complex chemical process called nitrogen fixation, which collects atmospheric nitrogen and converts it into organic forms that help the plant grow. When the plant dies, the excess nitrogen is released back into to the soil to help the next crop.

But often legumes are grown in areas with iron-depleted soil, which limits their nitrogen fixation. That's where research can lend a hand. The Argonne-UPM team has created the world's first model for how iron is transported in the plant's root nodule to trigger nitrogen fixation. This is the first step in modifying the plants to maximize iron use.

"The long-term goal is to help sustainable agriculture practices and further diminish the environmental damage from overuse of nitrogen fertilizers," said Manuel Gonzalez-Guerrero, lead author of the paper from UPM. "This can be done by maximizing the delivery of essential metal oligonutrients to nitrogen-fixing rhizobia."

The research team, which included Lydia Finney and Stefan Vogt from the APS, used high-energy X-rays from the 8-BM and 2-ID-E beamlines of the APS to track the distribution of minute iron amounts in the different developmental regions of rhizobia-containing roots. This is the first high-energy X-ray analysis of plant-microbe interactions.

X-rays, such as those from the APS, provided a high sensitivity to elements and a high spatial resolution not attainable by other means. Full details can be found in the paper Iron distribution through the developmental stages of Medicago truncatula nodules.

In future studies at the APS, Gonzalez-Guerrero hopes to identify and characterize the key biological proteins responsible for iron transportation. That would give researchers targets to manipulate and screen for new legume varieties with increased nitrogen-fixation capabilities and higher nutritional value.

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The above story is reprinted from materials provided by DOE/Argonne National Laboratory. The original article was written by Tona Kunz.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Benjam?n Rodr?guez-Haas, Lydia Finney, Stefan Vogt, Pablo Gonz?lez-Melendi, Juan Imperial, Manuel Gonzalez-Guerrero. Iron distribution through the developmental stages of Medicago truncatula nodules. Metallomics, 2013; DOI: 10.1039/C3MT00060E

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/WFDVPPsK7IM/130423161911.htm

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Cigarette Makers Lose Challenge to Label Rule (WSJ)

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Israeli focus on Syria gives Hagel respite on Iran

JERUSALEM (AP) ? On Chuck Hagel's inaugural visit to Israel as U.S. defense secretary, Syria surpassed Iran as the security threat of greatest urgency to the U.S.' closest Mideast ally. That quite unexpectedly gave the new Pentagon chief a temporary respite from the delicate duty of tempering Israeli warnings about attacking Iran to stop it from building a nuclear bomb.

Israeli leaders see Iran's nuclear ambitions as a threat to their country's very existence, given Tehran's vow to wipe it off the map. But Syria suddenly has emerged so prominently that it overshadowed Iran during Hagel's three days in Israel.

That explains, in part, why Hagel repeatedly stressed in public Israel's right to defend itself and to decide on its own, if necessary, whether and when to attack Iran. He gave less emphasis than usual by American officials to Washington's wish that diplomacy and sanctions be given more time to persuade Iran to change course.

Notably, Israel's new defense minister, Moshe Yaalon, said at a joint news conference with Hagel on Monday that he, too, thinks non-military means ought to be pursued further.

"By one way or another, the military nuclear project of Iran should be stopped," Yaalon said. "Having said that, we believe that the military option, which is well discussed, should be the last resort anyhow." He added, "There are other tools to be used and to be exhausted, whether it is diplomacy, economic sanctions, or even more support of the opposition in Iran."

Hagel seemed to sense slightly less urgency in the Israeli concern about Iran, although he by no means dismissed the problem. One year ago, Hagel's predecessor, Leon Panetta, was letting it be known that he feared Israel could attack Iran in a matter of weeks. Washington worries that such a strike could ignite a wider war in which it would be difficult for the U.S. to avoid getting involved.

That was before the Syrian civil war had reached the point of widespread concern that its illicit stockpiles of chemical weapons could pose a threat to Israel and other neighbors.

Jordan, too, is worried about transfers of Syrian chemical weapons. Hagel stopped briefly in Jordan Tuesday.

"The United States and Jordan share mutual concerns about the ongoing crisis in Syria and continue to consult closely on a number of issues including chemical weapons and the demands posed by the influx of Syrian refugees fleeing the violence," Pentagon press secretary George Little said after Hagel's meeting in Amman.

Little said the Pentagon has provided more than $70 million to Jordan this year to help secure its border and prevent the transfer of chemical weapons from Syria.

Hagel ended his day in Riyadh, Saudi Arabia, where he met with Crown Prince Salman bin Abdulaziz al-Saud, who also serves as the Saudi defense minister. Little said they discussed a proposed sale of advanced U.S. missiles for Saudi F-15 fighters as well as mutual concerns about Iran's nuclear program and the violence in Syria.

The Israelis see immediate dangers in the Syrian civil war, not only in the threat along Israel's northeastern border but also in the grim possibility that Syrian chemical weapons could fall into the hands of extremists. Israel says each of those possibilities is a "red line" beyond which it would have to act.

The concern is that if President Bashar Assad is overthrown, any of the Islamic extremist groups trying to oust him could turn his extensive arsenal against Israel.

A senior Israeli military intelligence official said Tuesday that Assad has repeatedly used chemical weapons against insurgent groups. It was the first such public claim by Israel and appeared to increase pressure on Washington and other Western countries to intervene in Syria.

President Barack Obama has warned that the use of chemical weapons by Assad would be a "game changer." Little, the Pentagon press secretary, said Tuesday the U.S. government is still assessing reports of Syrian chemical weapons use, adding that such acts would be "entirely unacceptable." He did not elaborate on possible U.S. actions.

The White House said Tuesday the U.S. hasn't yet come to the conclusion that Assad has used chemical weapons even though close U.S. allies say he has.

In his assessment, Brig. Gen. Itai Brun, the head of research and analysis in Israeli military intelligence, told a security conference in Tel Aviv that Assad has used chemical weapons multiple times, including near Damascus, the capital, last month.

During Hagel's visit, Israeli leaders still emphasized the dangers of a nuclear-armed Iran ? as did Hagel. But to a degree not foreseen when Hagel arrived in Israel over the weekend, the threat posed by Syria's chemical weapons overshadowed Iran.

Hagel wrapped up his visit Tuesday by meeting with Prime Minister Benjamin Netanyahu, who greeted him with a brief but pointed caution about resolving the Iran problem. He complained of Iran arming terrorist groups with sophisticated weapons, and its "attempt to arm itself with nuclear weapons."

"This is a challenge that Israel cannot accept, and as you and President Obama have repeatedly said, Israel must be able to defend itself, by itself, against any threat," Netanyahu said.

___

Associated Press writer Ariel David contributed to this report.

Robert Burns can be followed on Twitter at http://www.twitter.com/robertburnsAP

Source: http://news.yahoo.com/israeli-focus-syria-gives-hagel-respite-iran-190331708--politics.html

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